WebJul 2, 2012 · Bw4 80T was also associated to protection against the disease (OR = 0.37, p = 0.001) but we did not find any association for Bw4 80I individually. We observed a strong and positive association for the presence of Bw6 (OR = 4.28, p<10 −3). We also analyzed the association between individuals who present only Bw4 epitopes, individuals carrying ... WebMismatching for Bw4 or Bw6 does not confer any independent, increased risk for humoral sensitization or renal allograft failure. AB - Background. Highly sensitized patients often have antibodies directed against the HLA Bw4 and Bw6 epitopes. Because of the high frequency of these epitopes, when present, these antibodies result in a high ...
HLA alleles determine differences in human natural killer cell ...
WebMay 1, 1979 · Although the Bw4/Bw6 antigen system was the first part of the HLA system to be described (van Rood 1962), it still re- presents one of the major stumbling blocks to the understanding of the... WebMar 1, 1995 · Using class I alleles HLA-B*1502 and B*1513 which differ only at residues 77-83 which define the Bw4 and Bw6 serological epitopes, we tested the hypothesis that the presence of the Bw4 epitope on class I molecules determines recognition by NKB1+ NK cells. HLA-B*1513 possesses the Bw4 epitope, whereas B*1502 has the Bw6 epitope. selling recalled merchandise
Variations in HLA-B cell surface expression, half-life and ...
Webthe Bw4 genotype but not the Bw6 genotype. Comparison of the entire population of donors revealed a strong correlation between the HLA-B genotype and NK cell responses. Upon tumor stimulation, the responsiveness of KIR3DL1 NK cells was significantly different among the Bw4/4, Bw4/6, and Bw6/6 groups (H 12.91, P 0.002; Fig. 2). WebHuman Leukocyte Antigen Allelic Associations With Disease Progression. We compared the allele frequencies of HLA-B*57, HLA-B*27, HLA-B*58, and HLA-B*35 between LTNPs and TPs. ... Because the Bw6 and Bw4 serotypes differ in their antigen recognition properties, their roles in determining disease progression are likely associated with the ... WebApr 17, 2014 · Genotyping of HLA-C1/C2 and HLA-Bw4/Bw6 ligand groups was performed as described in Hollenbach et al. 23 Briefly, genotyping was performed using a method developed using the SEQUENOM MassARRAY system with the primer extension reactions analyzed on the MALDI-TOF mass spectrometer. selling recalled products