Dual specificity protein phosphatase 1
WebApr 7, 2024 · The primary structure of PPP5C can be mainly divided into three parts, the N-terminal tetrapeptide repeat (TPR) domain (residues 28–129), the middle phosphatase domain (residues 175–490), and the C-terminal α-J helix (residues 490–499) [4] (Fig. 1 A).The TPR domain contains 34 amino acids which exert the autoinhibition functions of … WebLokareddy et al. (2013) obtained the 1.68-angstrom crystal structure of a catalytically inactive mutant (cys152 to ser) of DUSP26 lacking the first 60 N-terminal amino acids. DUSP26 adopted a closed conformation of the protein tyrosine phosphatase (PTP)-binding loop, resulting in a shallow active-site pocket and buried catalytic cysteine.
Dual specificity protein phosphatase 1
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WebApr 7, 2024 · The primary structure of PPP5C can be mainly divided into three parts, the N-terminal tetrapeptide repeat (TPR) domain (residues 28–129), the middle phosphatase … WebPTPN13 is a soluble and cytosolic non-receptor protein that can be translocated to the sub-membranous and nuclear compartments [ 7] during mitosis [ 8 ]. The PTPN13 gene is located on chromosome 4q21.3 and encodes the non-receptor protein phosphatase with the highest molecular weight (270 kDa; 2466 amino acids) [ 9 ].
WebSep 27, 2024 · LSF2 is a dual specificity protein phosphatase that displays high activity toward para-nitrophenyl phosphate ... Dietrich H, Servatius A, Howells N, Cato AC, Lang R (2006) Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203(1):15–20. WebDual specificity phosphatase 15 (Dusp15) represses myelin gene expression. Mag, Mbp, connexin 32 (Cx32), peripheral myelin protein 22 (Pmp22), and Srebp-1c mRNA levels …
WebMar 1, 2002 · Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3 (LMW-DSP3) ... PTHR46377 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 1 hit; PTHR46377:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 1 hit; PRINTS. PR01908 ADSPHPHTASE; PROSITE. View protein … WebJun 25, 2024 · Our previous study demonstrated that dual-specificity protein phosphatase 1 (DUSP1) reduced hyperglycemia-mediated mitochondrial damage; however, its role in hyperglycemia-driven dysfunction of tubular cells is still not fully understood. In this study, we found that DUSP1 is reduced in human proximal tubular …
WebApr 10, 2024 · dual specificity protein phosphatase CDC14A isoform 2 Download Models. Job ID Status Method Username Target Length Date (PST) Expiration Date (PST) 505201: Complete: Structure prediction : sabdus: dual specificity protein ... 623: 10 Apr 2024: 25 May 2024: 1 . 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . ...
WebMay 31, 1996 · Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Here, the crystal structure of a human DSP, … st mary\u0027s thatcham websiteWebIntroduction. Dual-specificity phosphatase 2 (DUSP2) belongs to the nuclear type I DUSP family and its molecular function is to terminate the activity of mitogen-activated protein kinases (MAPKs) including ERK1/2, p38 MAPK, and JNK 1.Since DUSP2 is predominantly expressed in immune cells, most studies have focused on the role of DUSP2 in the … st mary\u0027s theydon boisWebJan 1, 2015 · Dual-specificity protein phosphatase 1 (DUSP1), known also as MAP kinase phosphatase 1 (MKP1), is implicated in metabolism and energy expenditure. Mice lacking DUSP1 are resistant to high-fat diet-induced obesity. However, the expression of DUSP1 has not been investigated in human obesity. In the current study, we compared … st mary\u0027s thame churchWebIntroduction. Dual-specificity phosphatase 2 (DUSP2) belongs to the nuclear type I DUSP family and its molecular function is to terminate the activity of mitogen-activated protein … st mary\u0027s the mount catholic primary schoolWebDual specificity phosphatase 1 (DUSP1), a negative regulator of the mitogen‑activated protein kinase (MAPK) signaling pathway, has anti‑inflammatory properties. In the present study, the expression of DUSP1 was investigated in human OA fibroblast‑like synoviocytes (FLSs), human normal FLSs and OA FLSs pretreated with dexamethasone at the ... st mary\u0027s thetfordWebMar 7, 2006 · However, little is known on the functions of Ca 2+ /CaM-dependent protein kinases and phosphatases in Ca 2+ signaling in plants. From an Arabidopsis expression … st mary\u0027s thakeham west sussexWebJan 7, 2014 · Dual specificity protein phosphatase 1 (DUSP1) is a key negative regulator of mitogen activated protein kinases (MAPKs). Yet, DUSP1 is overexpressed in pancreatic cancer cells (PCCs) in PDAC where it paradoxically enhances colony formation in soft agar and promotes in vivo tumorigenicity. However, it is not known whether DUSP1 … st mary\u0027s theater