In molecular biology, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in … Meer weergeven This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. Meer weergeven HMG-CoA synthase contains an important catalytic cysteine residue that acts as a nucleophile in the first step of the reaction: the acetylation of the enzyme by acetyl-CoA (its first Meer weergeven HMG-CoA synthase occurs in eukaryotes, archaea, and certain bacteria. Eukaryotes In vertebrates, there are two different isozymes of … Meer weergeven • HMG-CoA+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Meer weergeven The systematic name of this enzyme class is acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common … Meer weergeven This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism. Meer weergeven As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XPK, 1XPL, 1XPM, and 2P8U. Meer weergeven WebMechanism of Action: An antihyperlipidemic that inhibits hydroxymethylglutaryl-CoA (HMG-CoA) reductase, the enzyme that catalyzes the early step in cholesterol synthesis. Therapeutic Effect: Decreases LDL and VLDL cholesterol, and plasma triglyceride levels; increases HDL cholesterol concentration.

A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the …

WebThe hydroxymethylglutaryl-CoA synthase ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 and HMG2 which are derived from a single ancestral HMGR gene by … WebHydroxymethylglutaryl-CoA synthase, mitochondrial EC number EC:2.3.3.10 ( UniProtKB ENZYME Rhea) By similarity Short names HMG-CoA synthase Alternative names 3-hydroxy-3-methylglutaryl coenzyme A synthase Gene names Name Hmgcs2 Organism names Organism Rattus norvegicus (Rat) Taxonomic identifier 10116 NCBI Taxonomic … breastscreen southside

Microorganisms Free Full-Text Genomic Comparison of …

Web3-hydroxy-3-methylglutaryl-coenzyme A C27H39N7O20P3S-5 - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 503 National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of … Web3-Hydroxy-3-methylglutaryl-CoA lyase (or HMG-CoA lyase) is an enzyme ( EC 4.1.3.4 that in human is encoded by the HMGCL gene located on chromosome 1. It is a key enzyme … Web3 mrt. 2010 · hydroxymethylglutaryl-CoA synthase. Synonyms (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) 3-hydroxy-3-methylglutaryl … breastscreen tamworth