Mechanism of cytosine arabinoside
WebApr 14, 2024 · The mechanism of action of ATRA was later discovered, ... Huang ME, Ye YC, Chen SR, Zhao JC, Gu LJ, Cai JR, et al. All-trans retinoic acid with or without low dose cytosine arabinoside in acute promyelocytic leukemia. report of 6 cases. Chin Med J (Engl) (1987) 100:949–53. WebDec 17, 2024 · Cytosine arabinase (cytarabine) is a chemotherapeutic agent used to treat a variety of cancers in humans and dogs. It quickly converts into a metabolite that damages DNA while the cell cycle is maintained in the S phase. …
Mechanism of cytosine arabinoside
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WebSuccessful modulation of high-dose cytosine arabinoside metabolism in acute myeloid leukaemia by haematopoietic growth factors: no effect of ribonucleotide reductase ... increase, P , 0·0001). To establish the mechanism respon-sible for these effects, the activity of the rate-limiting enzyme of AraC metabolism, deoxycytidine kinase (dCK), was ... WebC ytosine arabinoside (ara-c) is a synthetic antimetabolite that functions as a structural analogue of cytidine. The drug differs from the physiologic nucleoside by the presence of …
WebIt is not possible to rank the importance of these different potential mechanisms of cytotoxicity: RNA incorporation, dTTP depletion by thymidylate synthase inhibition, DNA incorporation, or damage to DNA … WebCytosine arabinoside (AraC) is a pyrimidine antimetabolite used clinically for the treatment of acute leukemia (for reviews, see Chabner, 1982; Kufe and Major, 1982; Pallavicini, 1984). ... spite extensive study, the precise mechanism of cellular death caused by AraC is not understood (Calabresi and Parks, 1985).
WebThese findings provide new insights into the mechanism of action of the most effective agent in the treatment of acute myelogenous leukemia. These findings have also been … WebStudies on the Mechanism of Action of Cytosine Arabinoside D.W. Kufe, MD, and P.P. Major, MD Sidney Farber Cancer Institute, Boston We have demonstrated that Ara-C incorporates …
WebArabinosylcytosine (l-β-D-arabinofuranosylcytosine; cytosine arabinoside; cytarabine; ara C) belongs to a class of nucleosides with D-arabinose as the pentose sugar moiety.The inversion of the 2′-hydroxyl group as compared with ribonucleosides (Fig. 1) conveys markedly different properties, and in many respects the arabinosides are biologically more …
premium bud light alcohol %WebSelection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene scott ackworthWebAug 12, 2024 · Mechanism of Action Cytarabine is a pyrimidine analog and is also known as arabinosylcytosine (ARA-C). It is converted into the triphosphate form within the cell and … scott a cleere idahoWebThe cytotoxicity of ara-C derives from an inhibition of DNA synthesis after incorporation of ara-CTP into DNA. The rate of DNA synthesis can be determined from the amount of bromodeoxy-uridine (BrdUrd) incorporated into cells after a short exposure to BrdUrd. premiumbuilder motion packWebThe mechanisms of lethal action of arabinosyl cytosine (araC) and arabinosyl adenine (araA) Seymour S. Cohen PhD, ... Certain D-arabinosyl nucleosides, notably arabinosyl cytosine (araC) and arabinosyl adenine (araA), are useful in the treatment of certain leukemias and some DNA virus infections, respectively. The compounds are lethal to … premium builder motion pack free downloadWebAug 6, 2013 · However, their mechanisms of action are different; ARA-C inhibits DNA synthesis whereas decitabine inhibits DNA methylation. Because both of these agents target the same cohort of leukemic cells in the S phase, they should produce an identical loss of survival at equal exposure times and therapeutic concentrations. scott ackmanWebKey words: cytosine arabinoside, DNA, leukemia INTRODUCTDN Ara-C is an effective agent in the treatment of acute myelogenous leukemia in man [ 14. The biochemical mechanisms responsible for this antitumor activity and selectivity have been unclear. Ara-C is an S-phase-specific agent [5-81 and the scott a clark