WebFeb 11, 2024 · Saccharothriolide F (3) was identified to be a demethylated congener of saccharothriolides D (1) and A (4) at the C-2 position. The availability of compounds 1–6 enabled a structure–activity relationship study that revealed the importance of the phenolic hydroxy group at C-2″ and the stereochemistry of C ... WebThe comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property of 2-aminophenol. Unexpectedly, 2-aminophenol in saccharothriolide B was eliminated through a retro-Michael reaction, to yield presaccharothriolide X under physiological conditions. 2 ...
Did you know?
WebJul 29, 2003 · This isolate makes a novel family of wide spectrum peptide antibiotics called the munumbicins [1]. It represents the first antibiotic-producing endophytic streptomycete to be recovered from a woody plant [1]. WebApr 11, 2024 · Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. Shan Lu, S. Nishimura, +7 authorsH. Kakeya Chemistry, Biology Chemical communications 2015 Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete …
WebDec 21, 2016 · Saccharothriolides A ( 3) and B ( 4) are expected to be Michael addition products of precursor A and the amino aryl groups, anthranilic acid and 2-aminophenol, … WebApr 30, 2024 · saccharide: [noun] a monosaccharide sugar or combination of sugars : carbohydrate.
WebFeb 1, 2024 · The focus of this review is bioactive macrolides obtained from rare actinomycetes, classified in terms of chemical structure, and covering the literature published until mid-2024. A total of 193 macrolides, in 26 groups, derived from 15 known and 2 unidentified rare actinomycetes are discussed. Chemical structures of … WebApr 11, 2024 · The production of saccharothriolides was enhanced. A new derivative of saccharothriolides, saccharothriolide C 2 Abstract A combined-culture method was …
WebMar 1, 2024 · The combined-culture not only enhanced saccharothriolide production, but also produced saccharothriolide C 2 , a new C-2 epimer of saccharothriolide C, thereby …
WebA combined-culture method was applied to saccharothriolide-producing strain Saccharothrix sp. A1506 with the mycolic acid-containing bacterium (MACB) Tsukamurella pulmonis TP-B0596. The combined-culture not only enhanced saccharothriolide production, but also produced saccharothriolide C2, a new C-2 epimer of saccharothriolide C, thereby ... nip it breath freshenerWebAug 3, 2024 · Unexpectedly, 2-aminophenol in saccharothriolide B was eliminated through a retro-Michael reaction, to yield presaccharothriolide X under physiological conditions. 2 … numbers americanWebJul 19, 2024 · Request PDF Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506 The highly reactive precursor ... numbers american express cards start withWebJul 27, 2016 · Yulu Jiang, Shan Lu, Go Hirai, Taira Kato, Hiroyasu Onaka, Hideaki Kakeya, Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis, Tetrahedron Letters, 10.1016/j.tetlet.2024.03.034, (2024). nip it golf longview texasWebThe growth of Trypanosoma cruzi in two liquid media has been studied. Both media contain NaCl, KCl, phosphate buffer, glucose, calf serum and hemoglobin. In addition, the medium that supports faster growth contained liver infusion and tryptose (LIT medium), while the other contained lactalbumin hydrolyzate. nipith charoenngamWebSep 1, 2015 · Saccharothriolide B (Ib) demonstrates moderate cytotoxicity against cancer cell lines HeLa and HT1080. Saccharothriolide B (Ib) demonstrates moderate cytotoxicity against cancer cell lines HeLa and HT1080. numbers and a. b. cWebSaccharothriolides A-C, novel phenyl-substituted 10-membered macrolides from a rare actinomyceteSaccharothrixsp. Shan Lu,aShinichi Nishimura,aGo Hirai,b Masashi Ito,c Teppei Kawahara,dMiho Izumikawa,d Mikiko Sodeoka,b Kazuo Shin … nipit hand stopper