Star-related lipid transfer protein 5
Webb18 mars 2013 · The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped … WebbAlthough the intermembrane transfer reaction catalyzed by LTPs is an equilibrium reaction, various types of newly synthesized lipids are transported unidirectionally in cells. This …
Star-related lipid transfer protein 5
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Webbthat oxysterol-binding protein-related proteins [22] are likely involved in cholesterol transport. As a control, an irrelevant protein with the His tag (NAD kinase, rNADK) was used (Fig 1C). EhLTP1 and EhLTP3 have distinct PIs transfer activities Since EhLTP1 and EhLTP3 bound mostly to PI(4)P, PtdIns(4,5)P 2, and PtdIns(3,4,5)P 3 in Webb1 jan. 2014 · The StAR-related lipid transfer domain, abbreviated START , was first described by Ponting and Aravind [] as a region of sequence similarity shared between a rat RhoGAP protein, plant Gla2 family members, mouse and human StAR , and bovine phosphatidylcholine transfer protein.Thus, the START domain was identified as a result …
Webb3 aug. 2007 · StarD10 is a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes in vitro. We now provide evidence that, in vivo, StarD10 is phosphorylated on serine 284. This novel phosphorylation site was identified by tandem mass spectro … Webb27 maj 2004 · The StAR-related lipid transfer (START) domain, named after the mammalian 30 kDa steroidogenic acute regulatory (StAR) protein that binds and transfers cholesterol to the inner mitochondrial membrane [], is defined as a motif of around 200 amino acids implicated in lipid/sterol binding [].Ligands have been demonstrated for a …
Webb8 sep. 2024 · The StAR-related lipid transfer (START) domain containing proteins or START proteins, encoded by a plant amplified family of evolutionary conserved genes, play important roles in lipid binding, transport, signaling, and modulation of transcriptional activity in the plant kingdom, but there is limited information on their evolution, … WebbThe steroidogenic acute regulatory protein (StAR) related lipid transfer (START) domains are 200–210 amino acid motifs that occur in a remarkably wide range of proteins …
WebbThe five human PI-transfer proteins can be divided into small proteins consisting of a single PI-transfer domain (PITD) including PITPα/β and PITPNC1, and the multi-domains containing proteins Nir2 and Nir3. Shown are the PITD, the FFAT motif, DDHD, and the C-terminal LNS2 (Lipin/Nde1/Smp2) domain.
WebbWe found that StARD3-overexpressing cells exhibited nonadherent morphological features, had increased Src levels, and had altered cholesterol balance, as evidenced by elevated mRNA levels of the cholesterol biosynthesis rate-limiting enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and increased plasma membrane cholesterol … flashinglight.comWebbThis gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. check exist element in array javascriptWebbStAR-related lipid transfer (START)1 domains are ∼210-amino acid lipid binding domains implicated in intracellular lipid transport, lipid metabolism, and cell signaling events. The … flashing light bulbs at walmartWebbSteroidogenic acute regulatory-related lipid transfer (START) domain proteins are involved in the nonvesicular intracellular transport of lipids and sterols. The STARD1 (STARD1 … flashing light bulbsWebb14 maj 2002 · There is a family of proteins with homology to StAR, each containing a 200- 210-aa StAR-related lipid transfer (START) domain ( 5 ). The START domain of MLN64/StarD3, which is 36% identical to StAR, has also been shown in vitro to bind cholesterol ( 6) and stimulate steroidogenesis ( 7 ). check existence of variable matlabWebb1 dec. 2012 · STARD1 (StAR) is the archetype of START domain-containing protein; it binds cholesterol, possesses a mitochondrial leader peptide, and is involved in the transfer of … check existence of session variableWebbStAR-related lipid transfer protein 5 (STARD5) [NX_Q9NSY2] May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity). Chromosomal location: 15q25.1 Isoforms: 2 PTMs: 0 … flashing light danby dishwasher ddw1801mw